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Rat Anesthetic and Analgesic drug dosages

 

  DOSE ROUTE FREQUENCY REFERENCE NOTES
           
PREMEDICATION          
Atropine 0.05-3 mg/kg SC, IM 36
Glycopyrolate 0.01-0.02 mg/kg SC
Acepromazine 0.5-2.5 mg/kg SC, IM, IV 36 as an adjunct to anesthesia
Diazepam 2-5 mg/kg SC, IP as an adjunct to anesthesia
Midazolam 2-5 mg/kg SC, IP
           
ANESTHETICS          
Ketamine 50-100 mg/kg SC, IP 36 best given with a sedative
Ketamine/Acepromazine 75/2.5 mg/kg SC, IP
Ketamine/Xylazine 50/5 mg/kg SC, IP 36
40-50 mcl/kg/min IV (CRI) 30:1 mix of ketamine:xylazine (ketamine 1 mg/kg/min; xylazine 35 mcg/kg/min)
Ketamine/Medetomidine 50/0.5 SC, IP 36
Telazol 20-40 mg/kg SC, IP 36
Pentobarbital 50-80 mg/kg IP
Propofol 10 mg/kg IV 36
Isoflurane, Halothane to effect inhalation
           
OPIOIDS          
Morphine 2-5 mg/kg SC q. 1 hr 13
10 mg/kg SC q. 2-4 hrs 16
Codeine 60-90 mg/kg SC q. 4 hrs 13
Meperidine 10-20 mg/kg SC, IM q. 2-3 hrs 13
Methadone 1-4 mg/kg SC 10
Pentazocine 10 mg/kg SC q. 4 hrs 1a
Buprenorphine 0.01-0.05 mg/kg  SC q. 6-12 hrs
0.015 mg/kg/hr IV 34
Nalbuphine 1-2 mg/kg IM q. 3 hrs 13
Butorphanol 2 mg/kg SC q. 4 hrs 13
           
NON-OPIOIDS          
Phenylbutazone 30-100 mg/kg PO q. 24 hrs 10
Aspirin 100 mg/kg PO q. 4 hrs 13
Carprofen 5 mg/kg SC, PO q. 12 hrs 36
Ketoprofen 5 mg/kg SC, IM, PO q. 24 hrs 36
Meloxicam 1-2 mg/kg SC, PO q. 12 hrs 36
Flunixin 1.1 mg/kg SC, IM q. 12 hrs 13
Ibuprofen 10-30 mg/kg PO q. 4 hrs 13
Acetaminophen 100-300 mg/kg PO q. 4 hrs 13
Xylazine 1-5 mg/kg SC, IP 36
Medetomidine 0.03-1.0 mg/kg SC, IP 36
           
ANESTHETIC ANTAGONIST          
Naloxone 0.01-0.1 mg/kg SC, IP, IV reverses opioids
Nalbuphine 1-4 mg/kg SC, IP partial reversal of opioids
Yohimbine 0.1-0.15 mg/kg IV reverses xylazine
Atipamezole 1 mg/kg IV reverses medetomidine